Heat olive oil in a skillet over medium-high heat.
Season chicken with smoked paprika, garlic powder, onion powder, salt, and pepper.
Cook chicken in skillet for about 10 minutes until golden and fully cooked.
Whisk honey and hot sauce together in a bowl, then toss with cooked chicken; keep warm.
Mix sour cream, chopped jalapeños, lime juice, and salt in a separate bowl; refrigerate until serving.
Lay one flour tortilla flat, sprinkle with cheddar and Monterey Jack cheese, then add hot honey chicken.
Add a light sprinkle of cheese and top with a second tortilla.
Melt butter in a skillet over medium heat.
Cook the assembled quesadilla for 2 to 3 minutes per side until golden brown and cheese is melted.
Slice into wedges, drizzle or serve with jalapeño cream sauce, and garnish with fresh cilantro.